[5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

Base Information

Chemical Name:[5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate
CAS No.:1248570-71-9
Molecular Formula:C₁₉H₂₆N₂O₉
Molecular Weight:426.423
Hs Code.:

Synonyms:[5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

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Chemical Property of [5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

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Technology Process of [5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

There total 3 articles about [5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: 1248570-62-8
3-(4-formyl-2-hydroxyphenoxy)propyl nitrate

: 1248570-71-9
[5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

Guidance literature:: 3-(tert-butyloxycarbonylamino)propionic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

3-(4-formyl-2-hydroxyphenoxy)propyl nitrate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201300105

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1248570-71-9
[5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogencarbonate / acetonitrile / 4 h / 70 °C

2.1: silver nitrate / acetonitrile / 14 h / 70 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With dmap; potassium hydrogencarbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300105

Reference yield:

: 1248570-61-7
4-(3-bromopropoxy)-3-hydroxybenzaldehyde

: 1248570-71-9
[5-formyl-2-(4-nitrooxybutoxy)phenyl]-3-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver nitrate / acetonitrile / 14 h / 70 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With dmap; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300105