ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate

Base Information

• Chemical Name: ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate
• CAS No.: 103367-97-1
• Molecular Formula: C₂₁H₃₂NO₉P
• Molecular Weight: 473.46
• Mol file: 103367-97-1.mol

Synonyms:ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate

Chemical Property of ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate

There total 2 articles about ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

diethyl ((2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)methyl)phosphinate (81956-28-7) + ethyl 2-{[(2,4-dimethoxyphenyl)methyl]amino}acetate (95218-34-1) → ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate (103367-97-1)

Guidance literature:

In xylene; at 160 ℃; for 1h;

DOI:10.1021/ja00278a031

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate (103367-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / Et₃N, NaBH₄ / ethanol; methanol / 1 h / Ambient temperature

2: 69 percent / xylene / 1 h / 160 °C

With sodium tetrahydroborate; triethylamine; In methanol; ethanol; xylene;

DOI:10.1021/ja00278a031

Reference yield: 65.0%

ethyl N-(4-(diethoxyphosphinyl)-3-oxobutanoyl)-N-(2,4-dimethoxybenzyl)glycinate (103367-97-1) → 3-(1-hydroxy-2-(diethoxyphosphinyl)ethylidene)-1-(2,4-dimethoxybenzyl)-2,4-pyrrolidinedion (103367-98-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 16h; Ambient temperature;

DOI:10.1021/ja00278a031

upstream raw materials:

diethyl ((2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)methyl)phosphinate

ethyl 2-{[(2,4-dimethoxyphenyl)methyl]amino}acetate

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

3-(1-hydroxy-2-(diethoxyphosphinyl)ethylidene)-1-(2,4-dimethoxybenzyl)-2,4-pyrrolidinedion

<1R*-<1β,2α,4α,6β,7α,8β(1E,2E,4E,6R*)>>-1-(2,4-dimethoxybenzyl)-3-<1-hydroxy-4-methyl-6-(1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo<4.3.1.0(2,4)>dec-8-yl)-2,4-heptadienylidene>-2,4-pyrrolidinedione