isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Base Information

Chemical Name:isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate
CAS No.:1428526-55-9
Molecular Formula:C₂₀H₂₁N₄O₅P
Molecular Weight:428.384
Hs Code.:

Synonyms:isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

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Chemical Property of isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

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Technology Process of isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

There total 6 articles about isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1428526-54-8
diisopropyl (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

: 1428526-55-9
isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; for 48h; Reflux;

Reference yield:

: 100-52-7
benzaldehyde

: 1428526-55-9
isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 48 h / 20 - 60 °C / Molecular sieve

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: sodium hydroxide / tetrahydrofuran; methanol; water / 48 h / Reflux

With ammonium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 112564-57-5
diisopropyl [amino(phenyl)methyl]phosphonate

: 1428526-55-9
isopropyl hydrogen (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: sodium hydroxide / tetrahydrofuran; methanol; water / 48 h / Reflux

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;