trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid

Base Information

• Chemical Name: trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid
• CAS No.: 71550-81-7
• Molecular Formula: C₁₁H₁₈O₃
• Molecular Weight: 198.262
• Mol file: 71550-81-7.mol

Synonyms:trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid

Chemical Property of trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid

There total 3 articles about trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-methyl 2-formylcyclohexanecarboxylate + 2-bromoprop-1-ene (557-93-7) + ammonium chloride → trans-2-(1-Hydroxy-2-methyl-2-propenyl)-cyclohexane carboxylic acid (71550-81-7)

Guidance literature:

With sodium hydroxide; magnesium; In tetrahydrofuran; benzene;

Reference yield:

methyl trans-2-formylcyclohexane-1-carboxylate (64109-98-4,105074-19-9,149564-35-2) → (1S,2S)-2-(1-Hydroxy-2-methyl-allyl)-cyclohexanecarboxylic acid (71550-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 0 - 5 °C

2: 1N NaOH / 1.5 h / Heating

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00345a011

Reference yield:

(1S,2S)-2-(1-Hydroxy-2-methyl-allyl)-cyclohexanecarboxylic acid methyl ester → (1S,2S)-2-(1-Hydroxy-2-methyl-allyl)-cyclohexanecarboxylic acid (71550-81-7)

Guidance literature:

With sodium hydroxide; for 1.5h; Heating;

DOI:10.1021/jm00345a011

upstream raw materials:

methyl trans-2-formylcyclohexane-1-carboxylate

2-bromoprop-1-ene

Downstream raw materials:

(1R,2R)-2-(1-Hydroxy-2-methyl-allyl)-cyclohexanecarboxylic acid benzhydryl ester

(1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester

diphenylmethyl trans-2-(1-oxo-2-methyl-2-propenyl)cyclohexanecarboxylate

trans-2-<3-(acetylthio)-2-methyl-1-oxopropyl>cyclohexanecarboxylic acid