(1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester

Base Information

• Chemical Name: (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester
• CAS No.: 71550-84-0
• Molecular Formula: C₂₆H₃₀O₄S
• Molecular Weight: 438.588
• Mol file: 71550-84-0.mol

Synonyms:(1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester

Chemical Property of (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester

There total 5 articles about (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diphenylmethyl trans-2-(1-oxo-2-methyl-2-propenyl)cyclohexanecarboxylate (71550-83-9) + tiolacetic acid (507-09-5) → (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester (71550-84-0)

Guidance literature:

In dichloromethane; for 2h;

DOI:10.1021/jm00345a011

Reference yield:

methyl trans-2-formylcyclohexane-1-carboxylate (64109-98-4,105074-19-9,149564-35-2) → (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester (71550-84-0)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 0.5 h / 0 - 5 °C

2: 1N NaOH / 1.5 h / Heating

3: ethyl acetate

4: Collins oxidation

5: 97 percent / CH₂Cl₂ / 2 h

With sodium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/jm00345a011

Reference yield:

(1S,2S)-2-(1-Hydroxy-2-methyl-allyl)-cyclohexanecarboxylic acid (71550-81-7) → (1R,2R)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-cyclohexanecarboxylic acid benzhydryl ester (71550-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethyl acetate

2: Collins oxidation

3: 97 percent / CH₂Cl₂ / 2 h

With Collins oxidation; In dichloromethane; ethyl acetate;

DOI:10.1021/jm00345a011

upstream raw materials:

diphenylmethyl trans-2-(1-oxo-2-methyl-2-propenyl)cyclohexanecarboxylate

tiolacetic acid

methyl trans-2-formylcyclohexane-1-carboxylate

(1S,2S)-2-(1-Hydroxy-2-methyl-allyl)-cyclohexanecarboxylic acid

Downstream raw materials:

trans-2-(3-mercapto-2-methyl-1-oxopropyl)cyclohexanecarboxylic acid

trans-2-<3-(acetylthio)-2-methyl-1-oxopropyl>cyclohexanecarboxylic acid