3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

Base Information

Chemical Name:3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid
CAS No.:1411991-97-3
Molecular Formula:C₂₆H₂₇BN₂O₄
Molecular Weight:442.322
Hs Code.:

Synonyms:3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

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Chemical Property of 3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

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Technology Process of 3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

There total 6 articles about 3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1411992-99-8
C₃₁H₃₅BN₂O₆

: 1411991-97-3
3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

Guidance literature:: With trifluoroacetic acid; In acetonitrile; at 20 ℃; for 12h;

Reference yield:

: 909072-54-4
2H-spiro[benzofuran-3,4′-piperidine]-5-carbonitrile

: 1411991-97-3
3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 - 20 °C

2: methanol; sodium tetrahydroborate; nickel dichloride / 0 - 20 °C

3: 0 - 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Autoclave

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

6: trifluoroacetic acid / acetonitrile / 12 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1411994-27-8
C₂₁H₂₄N₂O₃

: 1411991-97-3
3′-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Autoclave

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

4: trifluoroacetic acid / acetonitrile / 12 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;