2,2,2-Trifluoro-1-(4-methylphenyl)-O-[(4-methylphenyl)sulfonyl]oxime ethanone

Base Information

• Chemical Name: 2,2,2-Trifluoro-1-(4-methylphenyl)-O-[(4-methylphenyl)sulfonyl]oxime ethanone
• CAS No.: 87736-79-6
• Molecular Formula: C16H14 F3 N O3 S
• Molecular Weight: 357.353
• Mol file: 87736-79-6.mol

Synonyms:4-Methyl-a,a,a-trifluoroacetophenone oxime tosylate

Chemical Property of 2,2,2-Trifluoro-1-(4-methylphenyl)-O-[(4-methylphenyl)sulfonyl]oxime ethanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 396.87°C at 760 mmHg
• Flash Point: 193.82°C
• PSA: 64.11000
• Density: 1.29g/cm³
• LogP: 5.05610
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2,2,2-Trifluoro-1-(4-methylphenyl)ethanoneO-TosylOxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2,2-Trifluoro-1-(4-methylphenyl)ethanone O-Tosyl Oxime (cas# 87736-79-6) is a compound useful in organic synthesis.

Technology Process of 2,2,2-Trifluoro-1-(4-methylphenyl)-O-[(4-methylphenyl)sulfonyl]oxime ethanone

There total 8 articles about 2,2,2-Trifluoro-1-(4-methylphenyl)-O-[(4-methylphenyl)sulfonyl]oxime ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone oxime (75703-25-2,92512-68-0) + p-toluenesulfonyl chloride (98-59-9) → 2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone O-(p-tolylsulfonyl)oxime (87736-79-6)

Guidance literature:

In pyridine; for 3h; Heating;

Reference yield:

2,2,2-trifluoro-1-(p-tolyl)ethanone (394-59-2) → 2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone O-(p-toulenesulfonyl) oxime (87736-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine

2: pyridine

With pyridine; hydroxylamine;

DOI:10.1246/cl.2006.1172

Reference yield:

para-bromotoluene (106-38-7) → 2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone O-(p-toulenesulfonyl) oxime (87736-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / n-BuLi

2: hydroxylamine; pyridine / ethanol

3: pyridine

With pyridine; n-butyllithium; hydroxylamine; In ethanol;

DOI:10.1021/jm050583t

upstream raw materials:

2,2,2-trifluoro-1-(p-tolyl)ethanone

p-toluenesulfonyl chloride

para-bromotoluene

2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone oxime

Downstream raw materials:

3-(4-methylphenyl)-3-trifluoromethyldiaziridine

4-[3-(trifluoromethyl)-3H-diaziren-3-yl]toluene

1-<<4-<3-(trifluoromethyl)-3H-diazirin-3-yl>benzoyl>oxy>-2,5-pyrrolidinedione

4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic acid