ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate
• CAS No.: 943904-72-1
• Molecular Formula: C₁₈H₂₀INO₄
• Molecular Weight: 441.266
• Mol file: 943904-72-1.mol

Synonyms:ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate

Chemical Property:

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Technology Process of ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate

There total 1 articles about ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid (943904-73-2) → ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate (943904-72-1)

Guidance literature:

With iodine; sodium hydrogencarbonate; potassium iodide; In ethanol; water; at 70 ℃;

DOI:10.1002/jhet.5570440338

Reference yield: 55.0%

ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate (943904-72-1) → diethyl 3,3'-bis(benzyloxycarbonyl)-4,4'-dipropyl-2,2'-bipyrrole-3,3',5,5'-tetracarboxylate (943904-71-0)

Guidance literature:

With copper; In N,N-dimethyl-formamide; for 15h;

DOI:10.1002/jhet.5570440338

Reference yield:

ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate (943904-72-1) → diethyl 3,3'-bis(benzyloxycarbonyl)-4,4'-dipropyl-2,2'-bipyrrole-3,3',5,5'-tetracarboxylate (943904-71-0) + C18H21NO4 (1260184-09-5)

Guidance literature:

With copper; In N,N-dimethyl-formamide;

DOI:10.1007/s00706-008-0034-1

upstream raw materials:

3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid

Downstream raw materials:

diethyl 3,3'-bis(benzyloxycarbonyl)-4,4'-dipropyl-2,2'-bipyrrole-3,3',5,5'-tetracarboxylate

C₁₈H₂₁NO₄