(S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

Base Information

Chemical Name:(S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one
CAS No.:1333469-53-6
Molecular Formula:C₂₃H₄₂O₄Si₂
Molecular Weight:438.755
Hs Code.:

Synonyms:(S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

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Technology Process of (S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

There total 3 articles about (S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 39652-80-7,98498-56-7,125074-06-8,111556-27-5
(S)-2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

: 1333469-53-6
(S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

Guidance literature:: With 1H-imidazole; In acetone; at 20 ℃; for 2h;
DOI:10.1021/np2003319

Reference yield:

: 1730-91-2
(S)-2-Methylbutyric acid

: 1333469-53-6
(S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / 80 °C

2.1: aluminum (III) chloride / carbon disulfide; nitrobenzene / 1 h / 20 - 55 °C

2.2: 1 h / 55 °C

3.1: 1H-imidazole / acetone / 2 h / 20 °C

With 1H-imidazole; aluminum (III) chloride; thionyl chloride; In carbon disulfide; nitrobenzene; acetone;
DOI:10.1021/np2003319

Reference yield:

: 27763-54-8
(S)-2-methylbutanoyl chloride

: 1333469-53-6
(S)-1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-methylbutan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / carbon disulfide; nitrobenzene / 1 h / 20 - 55 °C

1.2: 1 h / 55 °C

2.1: 1H-imidazole / acetone / 2 h / 20 °C

With 1H-imidazole; aluminum (III) chloride; In carbon disulfide; nitrobenzene; acetone;
DOI:10.1021/np2003319