4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

Base Information

Chemical Name:4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid
CAS No.:1000611-92-6
Molecular Formula:C₂₄H₂₈N₄O₆S₂
Molecular Weight:532.642
Hs Code.:

Synonyms:4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

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Chemical Property of 4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

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Technology Process of 4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

There total 6 articles about 4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (S)-1-((S)-2-(4-aminophenyl)-1-(4-ethylthiazol-2-yl)ethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1000611-92-6
4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

Guidance literature:: With 4-methyl-morpholine; sulfur trioxide trimethylamine complex; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

: 1000394-25-1
1-(S)-(4-ethylthiazol-2-yl)-2-(4-nitrophenyl)ethyl amine hydrobromide

: 1000611-92-6
4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: pyrographite; iron(III) chloride; hydrazine hydrate / ethanol / 3 h / Reflux

3: sulfur trioxide trimethylamine complex; 4-methyl-morpholine / tetrahydrofuran / 3 h / 50 °C

With 4-methyl-morpholine; iron(III) chloride; sulfur trioxide trimethylamine complex; pyrographite; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1000611-92-6
4-{(S)-2-(4-ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: Lawessons reagent / tetrahydrofuran / 3 h / 20 °C

3.1: acetonitrile / 3 h / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

5.1: pyrographite; iron(III) chloride; hydrazine hydrate / ethanol / 3 h / Reflux

6.1: sulfur trioxide trimethylamine complex; 4-methyl-morpholine / tetrahydrofuran / 3 h / 50 °C

With Lawessons reagent; 4-methyl-morpholine; iron(III) chloride; sulfur trioxide trimethylamine complex; pyrographite; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;