3-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)propanoic acid

Base Information

• Chemical Name: 3-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)propanoic acid
• CAS No.: 120709-59-3
• Molecular Formula: C₁₆H₂₂N₂O₆
• Molecular Weight: 338.36
• Mol file: 120709-59-3.mol

Synonyms:2-(((1,1-Dimethylethoxy)carbonyl)amino)-3-(((phenylmethoxy)carbonyl)amino)propanoic acid

Chemical Property of 3-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)propanoic acid

Chemical Property:

• Boiling Point: 548.7±50.0 °C(Predicted)
• PKA: 3.68±0.10(Predicted)
• Density: 1.235±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)propanoic acid

There total 4 articles about 3-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + Nα-Boc-α,β-diaminopropionic acid (159002-17-2) → 2-(((1,1-Dimethylethoxy)carbonyl)amino)-3-(((phenylmethoxy)carbonyl)amino)propanoic acid (120709-59-3,81306-93-6)

Guidance literature:

With potassium carbonate; potassium hydroxide; In tetrahydrofuran; water; at -5 - 25 ℃; for 16h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-3-benzyloxycarbonylaminopropionic acid (61177-01-3) → 2-(((1,1-Dimethylethoxy)carbonyl)amino)-3-(((phenylmethoxy)carbonyl)amino)propanoic acid (120709-59-3,81306-93-6)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + benzyl chloroformate (501-53-1,94274-21-2) + Nα-Boc-α,β-diaminopropionic acid (159002-17-2) → 2-(((1,1-Dimethylethoxy)carbonyl)amino)-3-(((phenylmethoxy)carbonyl)amino)propanoic acid (120709-59-3,81306-93-6)

Guidance literature:

With hydrogenchloride; sodium carbonate;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-3-benzyloxycarbonylaminopropionic acid

benzyl chloroformate

N^α-Boc-α,β-diaminopropionic acid

Downstream raw materials:

N^α-Boc-α,β-diaminopropionic acid

(R)-4-(2-Amino-3-benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

Boc-DL-Dap(Z)-D-Glu(OBzl)-NH₂

{2-[1-(benzyloxycarbonylamino-methyl)-3-chloro-2-oxo-propylcarbamoyl]-2-tert-butoxycarbonylamino-ethyl}-carbamic acid benzyl ester

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