Methyl 3-hydroxypyrrolidine-1-carboxylate

Base Information

Chemical Name:Methyl 3-hydroxypyrrolidine-1-carboxylate
CAS No.:83487-19-8
Molecular Formula:C₆H₁₁NO₃
Molecular Weight:145.158
Hs Code.:
European Community (EC) Number:825-523-9
Mol file:83487-19-8.mol

Synonyms:methyl 3-hydroxypyrrolidine-1-carboxylate;83487-19-8;SCHEMBL6484170;1-Methoxycarbonylpyrrolidin-3-ol;AKOS012215164;AT22495;CS-0225732;EN300-1247670

Suppliers and Price of Methyl 3-hydroxypyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Methyl3-hydroxypyrrolidine-1-carboxylate
1g
$ 637.00

AK Scientific
Methyl3-hydroxypyrrolidine-1-carboxylate
500mg
$ 503.00

Total 4 raw suppliers

Chemical Property of Methyl 3-hydroxypyrrolidine-1-carboxylate

Chemical Property:

PSA：49.77000
LogP:-0.24270
XLogP3:-0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:145.07389321
Heavy Atom Count:10
Complexity:137

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-hydroxypyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)N1CCC(C1)O

Technology Process of Methyl 3-hydroxypyrrolidine-1-carboxylate

There total 4 articles about Methyl 3-hydroxypyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-22-1
methyl chloroformate

: 111810-68-5
3-hydroxypyrrolidine hydrochloride

: 83487-19-8
N-carbomethoxy-3-hydroxypyrrrolidine

Guidance literature:: 3-hydroxypyrrolidine hydrochloride; With sodium carbonate; In diethyl ether; at 20 ℃; for 0.333333h;

methyl chloroformate; In diethyl ether; at 20 ℃;
DOI:10.1021/ja053337f

Reference yield:

: 76460-88-3
N-methoxycarbonyl-2,3-dihydropyrrole

: 83487-19-8
N-carbomethoxy-3-hydroxypyrrrolidine

Guidance literature:: With sodium tetrahydroborate; dihydrogen peroxide; Yield given. Multistep reaction; 1.) THF, -20 deg C, 7-8 h, 2.) 3N NaOH;
DOI:10.1021/ja00388a037

Reference yield:

: 56475-80-0
N-(methoxycarbonyl)pyrrolidine

: 83487-19-8
N-carbomethoxy-3-hydroxypyrrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: anodic oxidation in tetraethylammonium p-toluenesulfonate

2: 91 percent / NH₄Cl / 3 h / 20 - 100 Torr / Heating

3: 1.) sodium borohydride-boron trifluoride etherate, 2.) H₂O₂ / 1.) THF, -20 deg C, 7-8 h, 2.) 3N NaOH

With sodium tetrahydroborate; dihydrogen peroxide; ammonium chloride;
DOI:10.1021/ja00388a037