111810-68-5

Basic information

• Product Name: 3-hydroxypyrrolidine hydrochloride
• CAS NO: 111810-68-5
• Molecular Weight: 123.582
• Mol File: 111810-68-5.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 3-hydroxypyrrolidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxypyrrolidine hydrochloride(111810-68-5)
• EPA Substance Registry System: 3-hydroxypyrrolidine hydrochloride(111810-68-5)

Safety Data

• Hazardous Substances Data: 111810-68-5(Hazardous Substances Data)

Upstream product

• 101469-91-4 (3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 51-35-4 4R-4-hydroxyproline 
• 130680-56-7 (3R)-N-acetyl-3-(tert-butyldimethylsilyloxy)propylamine 
• 127913-44-4 (S)-4-chloro-3-hydroxy butyronitrile 

Downstream Products

• 1429414-83-4 5-(3-hydroxypyrrolidin-1-yl)picolinonitrile 
• 1072227-55-4 (S)-3-chloro-pyrrolidine hydrochloride 
• 1315054-87-5 C₇H₁₄N₂O₂ 
• 1315054-87-5 C₇H₁₄N₂O₂ 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 

Relevant articles and documents

Hydrogenation of chiral nitrile on highly ordered mesoporous carbon-supported Pd catalysts

A highly ordered mesoporous carbon (C-SBA-15 and C-SBA-16) was synthesized by nanocasting method using its corresponding mesoporous silica (SBA-15 and SBA-16) as a template. The obtained porous carbons have high surface areas, large pore volume and a narrow pore size distribution. The N2-adsorption data for C-SBA-15 have provided the BET area of 2029 m2 g-1 and the total pore volume of 1.7 cm3 g-1, and 1637 m2 g-1 and 1.1 cm3 g-1 for C-SBA-16, respectively. The palladium metal impregnated carbon catalysts were employed in the synthesis of (S)-3-pyrrolidinol from chiral (S)-4-chloro-3-hydroxybutyronitrile, and a high yield to (S)-3-pyrrolidinol-salt was obtained by using 1 wt% Pd/C-SBA-16. It was investigated that the well-dispersed Pd metals in the confined mesopores are efficient for the hydrogenation of cyano groups to amine.

COMPOUNDS

Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).

A PROCESS FOR PREPARATION OF (2S, 5R)-7-OXO-N-[(3S)-PYRROLIDIN-3-YLOXY]-6-(SULFOOXY)-1,6-DIAZABICYCLO [3.2.1]OCTANE-2-CARBOXAMIDE

A process for preparation of a compound of Formula (I) is disclosed.