(S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

Base Information

Chemical Name:(S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one
CAS No.:220428-23-9
Molecular Formula:C₁₄H₁₆Cl₂N₂O₄S
Molecular Weight:379.264
Hs Code.:

Synonyms:(S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

Suppliers and Price of (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

Chemical Property:

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Technology Process of (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

There total 1 articles about (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93783-15-4
3,3-dichloro-2-oxoindoline-5-sulfonyl chloride

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 220428-23-9
(S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.01.110

Reference yield:

: 220428-23-9
(S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

: 1292809-48-3
(S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; acetic acid / 90 °C

2.1: caesium carbonate / acetonitrile / 0.17 h / 20 °C

2.2: 4 h / 20 °C

3.1: copper(II) sulfate; sodium L-ascorbate / methanol; water / 72 h / 20 °C

With caesium carbonate; copper(II) sulfate; sodium L-ascorbate; In methanol; water; acetic acid; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.110

Reference yield:

: 220428-23-9
(S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one

: 1292809-57-4
(S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-5-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

: 1292809-49-4
(S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; acetic acid / 90 °C

2.1: caesium carbonate / acetonitrile / 0.17 h / 20 °C

2.2: 4 h / 20 °C

3.1: methanol / 70 °C / Inert atmosphere

With caesium carbonate; In methanol; water; acetic acid; acetonitrile; 3.1: Huisgen cycloaddition reaction;
DOI:10.1016/j.bmcl.2011.01.110