1292809-49-4

Basic information

• Product Name: (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
• Synonyms: (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
• CAS NO: 1292809-49-4
• Molecular Weight: 557.63
• Mol File: 1292809-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione(1292809-49-4)
• EPA Substance Registry System: (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione(1292809-49-4)

Safety Data

• Hazardous Substances Data: 1292809-49-4(Hazardous Substances Data)

Upstream product

• 220509-74-0 (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin 
• 91-56-5 indole-2,3-dione 
• 93783-15-4 3,3-dichloro-2-oxoindoline-5-sulfonyl chloride 
• 1292809-64-3 (S)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)-1-(prop-2-yn-1-yl)indoline-2,3-dione 
• 31656-91-4 4-azidobiphenyl 
• 220428-23-9 (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one 

Relevant articles and documents

Isatin 1,2,3-triazoles as potent inhibitors against caspase-3

Sixteen disubstituted 1,2,3-triazoles were prepared using the Huisgen cycloaddition reaction and evaluated as inhibitors against caspase-3. The two most potent inhibitors were found to be (S)-1-((1-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-((2-(methoxymethyl)pyrrolidin-1-yl) sulfonyl)indoline-2,3-dione (7f) and (S)-1-((1-benzyl-1H-1,2,3-triazol-5-yl) methyl)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione (8g) with IC50-values of 17 and 9 nM, respectively. Lineweaver-Burk plots revealed that these two triazoles show competitive inhibitory mechanism against caspase-3.