(alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol

Base Information

Chemical Name:(alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol
CAS No.:74936-96-2
Molecular Formula:C₁₁H₁₅NO
Molecular Weight:177.246
Hs Code.:
DSSTox Substance ID:DTXSID301282084
Nikkaji Number:J1.011.339C

Synonyms:(~{S})-phenyl-[(2~{S})-pyrrolidin-2-yl]methanol;(alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol;SCHEMBL20482096;DTXSID301282084;74936-96-2

Suppliers and Price of (alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:177.115364102
Heavy Atom Count:13
Complexity:154

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(NC1)C(C2=CC=CC=C2)O
Isomeric SMILES:C1C[C@H](NC1)[C@H](C2=CC=CC=C2)O

Technology Process of (alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol

There total 15 articles about (alphaS,2S)-alpha-Phenyl-2-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 913642-87-2
(1S,2S)-2-(hydroxy(phenyl)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 74936-96-2
(S)-α-<(S)-pyrrolidin-2-yl>benzyl alcohol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1055/s-0029-1217568

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 74936-96-2
(S)-α-<(S)-pyrrolidin-2-yl>benzyl alcohol

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH

2: 1.) Ph₂POCl

3: potassium tri(sec-butyl)borohydride

4: KOH / methanol

With potassium hydroxide; sodium hydroxide; potassium tri-sec-butyl-borohydride; Diphenylphosphinic chloride; In methanol;
DOI:10.1021/ja00257a034

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 74936-96-2
(S)-α-<(S)-pyrrolidin-2-yl>benzyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Ph₂POCl

2: potassium tri(sec-butyl)borohydride

3: KOH / methanol

With potassium hydroxide; potassium tri-sec-butyl-borohydride; Diphenylphosphinic chloride; In methanol;
DOI:10.1021/ja00257a034