(E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

Base Information

Chemical Name:(E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol
CAS No.:1449464-89-4
Molecular Formula:C₁₉H₂₃ClN₂O₂S₂
Molecular Weight:410.989
Hs Code.:

Synonyms:(E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

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Chemical Property of (E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

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Technology Process of (E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

There total 3 articles about (E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1449464-79-2
(E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-3-(4-chlorophenyl)prop-2-en-1-ol

: 75-66-1
2-methylpropan-2-thiol

: 1449464-89-4
(E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -20 - -10 ℃; for 0.5h;
DOI:10.3987/COM-13-12677

Reference yield:

: 89466-42-2
4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

: 1449464-89-4
(E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / -20 - -10 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-13-12677

Reference yield:

: 1075-77-0
(E)-4-chlorocinnamic aldehyde

: 1449464-89-4
(E)-3-(4-chlorophenyl)-1-[4-(1,1-dimethylethylsulfanyl)-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / -20 - -10 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-13-12677