7-fluoro-2-nitro-4-phenyldibenzofuran

Base Information

• Chemical Name: 7-fluoro-2-nitro-4-phenyldibenzofuran
• CAS No.: 1357581-81-7
• Molecular Formula: C₁₈H₁₀FNO₃
• Molecular Weight: 307.281
• Mol file: 1357581-81-7.mol

Synonyms:7-fluoro-2-nitro-4-phenyldibenzofuran

Chemical Property of 7-fluoro-2-nitro-4-phenyldibenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 7-fluoro-2-nitro-4-phenyldibenzofuran

There total 5 articles about 7-fluoro-2-nitro-4-phenyldibenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-fluoro-4-iodo-2-nitrodibenzofuran (1360583-72-7) + phenylboronic acid (98-80-6) → 7-fluoro-2-nitro-4-phenyldibenzofuran (1357581-81-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 20h; Inert atmosphere;

DOI:10.1021/ol203442a

Reference yield:

2-(4-fluorophenyl)-4-nitro-6-phenylphenol (1357581-73-7) → 7-fluoro-2-nitro-4-phenyldibenzofuran (1357581-81-7) + 4-(4-fluorophenyl)-2-nitrodibenzofuran (1357581-82-8)

Guidance literature:

With copper diacetate; caesium carbonate; Trimethylacetic acid; In dimethyl sulfoxide; at 140 ℃; for 24h; air;

DOI:10.1021/ol203442a

Reference yield:

2-Phenylphenol (90-43-7,287950-96-3) → 7-fluoro-2-nitro-4-phenyldibenzofuran (1357581-81-7) + 4-(4-fluorophenyl)-2-nitrodibenzofuran (1357581-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid; acetic acid / 15 - 20 °C

2: iodine / dimethyl sulfoxide / 110 °C

3: palladium 10% on activated carbon; potassium carbonate / 1,4-dioxane; water / 10 h / 95 °C / air

4: copper diacetate; caesium carbonate; Trimethylacetic acid / dimethyl sulfoxide / 24 h / 140 °C / air

With palladium 10% on activated carbon; iodine; nitric acid; copper diacetate; potassium carbonate; caesium carbonate; acetic acid; Trimethylacetic acid; In 1,4-dioxane; water; dimethyl sulfoxide;

DOI:10.1021/ol203442a

upstream raw materials:

2-(4-fluorophenyl)-4-nitro-6-phenylphenol

7-fluoro-4-iodo-2-nitrodibenzofuran

phenylboronic acid

5-nitrobiphenyl-2-ol

Refernces