N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

Base Information

Chemical Name:N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine
CAS No.:1422361-69-0
Molecular Formula:C₂₀H₂₁Cl₂F₂N₃O₆
Molecular Weight:508.306
Hs Code.:

Synonyms:N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

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Chemical Property of N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

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Technology Process of N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

There total 7 articles about N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1422361-50-9
N-(2,6-dichlorophenyl)-3-(difluoromethoxy)-4-{3-[(2-oxotetrahydrofuran-3-yl)amino]propoxy}benzamide

: 1422361-69-0
N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2014.07.016

Reference yield:

: 1422361-83-8
3-(3-bromopropoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

: 1422361-69-0
N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / Reflux

2: lithium hydroxide / water; tetrahydrofuran / 0.5 h / 60 °C

With N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.bmcl.2014.07.016

Reference yield:

: 1422361-82-7
3-(3-bromopropoxy)-4-(difluoromethoxy)benzoic acid

: 1422361-69-0
N-{3-[4-{[(2,6-dichlorophenyl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]propyl}homoserine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / 1.5 h / 90 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 10 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / Reflux

4: lithium hydroxide / water; tetrahydrofuran / 0.5 h / 60 °C

With thionyl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2014.07.016