4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

Base Information

Chemical Name:4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate
CAS No.:1201818-40-7
Molecular Formula:C₂HF₃O₂*C₂₁H₂₄Cl₂N₂O₃
Molecular Weight:537.363
Hs Code.:

Synonyms:4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

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Chemical Property of 4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

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Technology Process of 4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

There total 14 articles about 4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201818-33-8
tert-butyl 4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 76-05-1
trifluoroacetic acid

: 1201818-40-7
4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 1201818-40-7
4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / water / 0.25 h / 20 °C

1.2: 24 h / 80 °C

1.3: 0.5 h

2.1: sulfuric acid / 4 h / Heating; Reflux

3.1: pyridine / 3 h / 5 °C

4.1: hydrogen; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethyl acetate; water

5.1: N-chloro-succinimide; acetic acid / water / 20 - 70 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 70 °C

7.1: dmap / tetrahydrofuran / 60 °C

8.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

9.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

10.1: dichloromethane / 4 h / 20 °C

With pyridine; dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 60531-36-4
4-(2-amino-ethyl)-benzoic acid hydrochloride

: 1201818-40-7
4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / water / 0.25 h / 20 °C

1.2: 24 h / 80 °C

1.3: 0.5 h

2.1: sulfuric acid / 4 h / Heating; Reflux

3.1: pyridine / 3 h / 5 °C

4.1: hydrogen; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethyl acetate; water

5.1: N-chloro-succinimide; acetic acid / water / 20 - 70 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 70 °C

7.1: dmap / tetrahydrofuran / 60 °C

8.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

9.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

10.1: dichloromethane / 4 h / 20 °C

With pyridine; dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;