Alanine, 3-fluoro-2-methyl-, methyl ester (9CI)

Base Information

• Chemical Name: Alanine, 3-fluoro-2-methyl-, methyl ester (9CI)
• CAS No.: 87492-66-8
• Molecular Formula: C₅H₁₀FNO₂
• Molecular Weight: 135.138
• Mol file: 87492-66-8.mol

Synonyms:Alanine, 3-fluoro-2-methyl-, methyl ester (9CI)

Chemical Property of Alanine, 3-fluoro-2-methyl-, methyl ester (9CI)

Chemical Property:

• PSA: 52.32000
• LogP: 0.54660

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Alanine, 3-fluoro-2-methyl-, methyl ester (9CI)

There total 1 articles about Alanine, 3-fluoro-2-methyl-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl 4-methyl-1,2,3-oxathiazolidine-4-carboxylic acid methyl ester 2,2-dioxide → methyl 2-amino-3-fluoro-2-methylpropanoate (87492-66-8)

Guidance literature:

N-tert-butoxycarbonyl 4-methyl-1,2,3-oxathiazolidine-4-carboxylic acid methyl ester 2,2-dioxide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 20 ℃;

With hydrogenchloride; In water; at 85 ℃; for 2h;

With thionyl chloride; In methanol; at 0 - 55 ℃; for 48h;

DOI:10.1002/ejoc.201900300

Reference yield:

methyl 2-amino-3-fluoro-2-methylpropanoate (87492-66-8) + benzyl bromide (100-39-0) → methyl 2-(benzylamino)-3-fluoro-2-methylpropanoate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 64h; Inert atmosphere;

DOI:10.1002/ejoc.201900300

Reference yield:

methyl 2-amino-3-fluoro-2-methylpropanoate (87492-66-8) + 2,4-Dimethoxybenzaldehyde (613-45-6) → methyl 2-((2,4-dimethoxybenzyl)amino)-3-fluoro-2-methylpropanoate

Guidance literature:

methyl 2-amino-3-fluoro-2-methylpropanoate; 2,4-Dimethoxybenzaldehyde; With triethylamine; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 20 ℃;

DOI:10.1002/ejoc.201900300