diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate

Base Information

• Chemical Name: diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate
• CAS No.: 197299-13-1
• Molecular Formula: C₂₅H₃₂O₅
• Molecular Weight: 412.526
• Mol file: 197299-13-1.mol

Synonyms:diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate

Chemical Property of diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate

There total 1 articles about diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diethyl butylmalonate (133-08-4) + 4-benzyloxybenzyl chloride (836-42-0) → diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate (197299-13-1)

Guidance literature:

diethyl butylmalonate; With sodium hydride; In N,N-dimethyl-formamide; toluene; at 40 ℃;

4-benzyloxybenzyl chloride; In N,N-dimethyl-formamide; toluene; at 20 ℃;

DOI:10.1016/j.bmc.2004.01.048

Reference yield: 86.0%

ethanol (64-17-5) + diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate (197299-13-1) → ethyl 2-(4-benzyloxybenzyl)hexanoate (197299-14-2)

Guidance literature:

diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate; With potassium hydroxide; In 2-methoxy-ethanol; water; at 130 ℃;

In xylene; Heating;

ethanol; With sulfuric acid; at 80 ℃;

DOI:10.1016/j.bmc.2004.01.048

Reference yield:

diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate (197299-13-1) → 2-(4-benzyloxybenzyl)-2-caproic acid + ethyl 2-(4-benzyloxybenzyl)hexanoate (197299-14-2)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

diethyl butylmalonate

4-benzyloxybenzyl chloride

Downstream raw materials:

ethyl 2-(4-benzyloxybenzyl)hexanoate

ethyl 2-(4-hydroxybenzyl)hexanoate

Refernces

• 1、 -. "Amidocarboxylic acid derivatives". . . Retrieved 2008/06/13.