(2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:(2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine
CAS No.:1431656-56-2
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:(2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

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Technology Process of (2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

There total 4 articles about (2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 102-96-5
(2-nitroethenyl)benzene

: 104-94-9
4-methoxy-aniline

: 123-38-6
propionaldehyde

: 1431656-56-2
(2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

Guidance literature:: (2-nitroethenyl)benzene; propionaldehyde; With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 4-nitro-phenol; In dichloromethane; at 20 ℃; for 0.25h;

4-methoxy-aniline; With 4-[(R)-((2S,4S,5R)-5-ethenyl-1-azabicyclo-[2.2.2]octan-2-yl)(hydroxy)methyl]quinolin-6-ol; In dichloromethane; at 0 ℃; for 48h; Solvent; Reagent/catalyst; Temperature; enantioselective reaction; Molecular sieve;
DOI:10.1039/c3cc40690c

Reference yield:

: 27675-37-2,3156-71-6
1-nitrobut-1-ene

: 106318-92-7
(4-Methoxy-phenyl)-[(E)-2-methyl-3-phenyl-prop-2-en-(E)-ylidene]-amine

: 1431656-56-2
(2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

: (2R,3S,4S)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

Guidance literature:: With bis(2-((S)-4-benzyl-4,5-dihydrooxazol-2-yl)-3-fluorophenyl)amine; zinc trifluoromethanesulfonate; In toluene; at 20 ℃; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/jacs.5b00033

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 104-94-9
4-methoxy-aniline

: 123-38-6
propionaldehyde

: 1431656-56-2
(2S,3R,4R)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

: (2R,3S,4S)-2-ethyl-1-(4-methoxyphenyl)-5-methyl-3-nitro-4-phenyl-1,2,3,4-tetrahydropyridine

Guidance literature:: (2-nitroethenyl)benzene; propionaldehyde; With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 4-nitro-phenol; In chloroform; at 20 ℃; for 0.25h;

4-methoxy-aniline; With Cinchonidin; In chloroform; at 0 ℃; for 48h; Overall yield = 34 %; enantioselective reaction; Molecular sieve;
DOI:10.1039/c3cc40690c