9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine

Base Information

• Chemical Name: 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine
• CAS No.: 76988-74-4
• Molecular Formula: C₂₅H₁₉Cl₂N₃O₂S
• Molecular Weight: 496.417

Synonyms:9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine

Chemical Property of 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine

Chemical Property:

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Technology Process of 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine

There total 2 articles about 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine (76988-73-3) + p-toluenesulfonyl chloride (98-59-9) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine (76988-74-4)

Guidance literature:

With pyridine; dmap; for 24h; Ambient temperature;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-39-1) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine (76988-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Zn, CH₃COOH / CH₂Cl₂ / 2 h / -30 °C

2: 78 percent / pyridine, 4-(dimethylamino)pyridine / 24 h / Ambient temperature

With pyridine; dmap; acetic acid; zinc; In dichloromethane;

DOI:10.1021/jm00365a009

Reference yield: 2.0%

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine (76988-74-4) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine 3-oxide (76988-76-6) + 8-chloro-6-(2-chlorophenyl)-5,6-dihydro-5-<(4-methylphenyl)sulfonyl>-4H-oxazolo<5,4-d><2>benzazepine (86709-92-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 50h; Ambient temperature;

DOI:10.1021/jm00365a009

upstream raw materials:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine

p-toluenesulfonyl chloride

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine

Downstream raw materials:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

8-chloro-6-(2-chlorophenyl)-5,6-dihydro-5-<(4-methylphenyl)sulfonyl>-4H-oxazolo<5,4-d><2>benzazepine

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