1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine

Base Information

Chemical Name:1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine
CAS No.:857759-22-9
Molecular Formula:C₁₆H₁₆N₂O
Molecular Weight:252.316
Hs Code.:
European Community (EC) Number:819-080-0
Mol file:857759-22-9.mol

Synonyms:1-benzoyl-1,2,3,4-tetrahydroquinolin-6-amine;857759-22-9;(6-amino-3,4-dihydro-2H-quinolin-1-yl)-phenylmethanone;1-benzoyl-3,4-dihydro-2H-quinolin-6-amine;MFCD09261804;AKOS000225323;MCULE-6025762829;CS-0241805;EN300-238337;G26690;F2189-0261;Z332724714

Suppliers and Price of 1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine
100mg
$ 214.00

Total 2 raw suppliers

Chemical Property of 1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:252.126263138
Heavy Atom Count:19
Complexity:325

Purity/Quality:

99% ^*data from raw suppliers

1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)N)N(C1)C(=O)C3=CC=CC=C3

Technology Process of 1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine

There total 7 articles about 1-Benzoyl-1,2,3,4-tetrahydroquinolin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 30450-57-8
(6-nitro-3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone

: 857759-22-9
(6-amino-3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone

Guidance literature:: With ammonium chloride; zinc; In methanol; water; at 60 ℃; for 6h;
DOI:10.1016/j.bioorg.2020.104501

Reference yield:

: 14026-45-0
6-nitro-1,2,3,4-tetrahydroquinoline

: 857759-22-9
(6-amino-3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: platinum; ethyl acetate; methanol / Hydrogenation

With pyridine; methanol; ethyl acetate; platinum;
DOI:10.1139/v52-084

Reference yield:

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 857759-22-9
(6-amino-3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: trialkylamine / dichloromethane / 24 h / 0 - 20 °C

2.1: potassium nitrate; sulfuric acid / dichloromethane / 2.5 h / 0 - 20 °C

3.1: pyrrolidine / dichloromethane

4.1: trialkylamine / dichloromethane / 0.5 h / 20 °C

4.2: 24 h / 20 °C

5.1: ammonium chloride; zinc / water; methanol / 6 h / 60 °C

With pyrrolidine; sulfuric acid; ammonium chloride; potassium nitrate; zinc; In methanol; dichloromethane; water;
DOI:10.1016/j.bioorg.2020.104501