(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester
CAS No.:1258451-23-8
Molecular Formula:C₁₉H₂₂N₂O₅S
Molecular Weight:390.46
Hs Code.:

Synonyms:(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

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Chemical Property of (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

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Technology Process of (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

There total 4 articles about (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1258451-22-7
(1R,2R,4R)-2-(1-cyanocyclopropylcarbamoyl)-4-phenylsulfanylcyclopentanecarboxylic acid ethyl ester

: 1258451-23-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 22 ℃;
DOI:10.1021/jm401528k

Reference yield:

: (1R,2R)-2-(1-cyanocyclopropylcarbamoyl)-4-methanesulfonyloxycyclopentanecarboxylic acid ethyl ester

: 1258451-23-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

1.2: 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jm401528k

Reference yield:

: 108-98-5
thiophenol

: 1258451-23-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

1.2: 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jm401528k