(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid
CAS No.:1258444-28-8
Molecular Formula:C₁₇H₁₈N₂O₅S
Molecular Weight:362.406
Hs Code.:

Synonyms:(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

Chemical Property:

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Technology Process of (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

There total 5 articles about (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258451-23-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid ethyl ester

: 1258444-28-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 22 ℃;
DOI:10.1021/jm401528k

Reference yield:

: (1R,2R)-2-(1-cyanocyclopropylcarbamoyl)-4-methanesulfonyloxycyclopentanecarboxylic acid ethyl ester

: 1258444-28-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

1.2: 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

With water; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/jm401528k

Reference yield:

: 1258451-22-7
(1R,2R,4R)-2-(1-cyanocyclopropylcarbamoyl)-4-phenylsulfanylcyclopentanecarboxylic acid ethyl ester

: 1258444-28-8
(1R,2R,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

With water; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm401528k