N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide

Base Information

• Chemical Name: N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide
• CAS No.: 1396243-18-7
• Molecular Formula: C₁₉H₁₆FNOS
• Molecular Weight: 325.407
• Mol file: 1396243-18-7.mol

Synonyms:N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide

Chemical Property of N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide

There total 3 articles about N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-bromo-N-(2-fluorophenyl)-N-methylthiophene-2-carboxamide (1396244-28-2) + m-tolylboronic acid (17933-03-8) → N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide (1396243-18-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 14h; Inert atmosphere;

DOI:10.1021/jm3014053

Reference yield: 86.0%

→ N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide (1396243-18-7)

Guidance literature:

Reference yield:

5-bromothiophene-2-carbonyl chloride (31555-60-9) + 2-fluoro-N-methylaniline (1978-38-7) → N-(2-fluorophenyl)-N-methyl-5-m-tolylthiophene-2-carboxamide (1396243-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 3 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 14 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; water;

DOI:10.1021/jm3014053

upstream raw materials:

5-bromothiophene-2-carbonyl chloride

2-fluoro-N-methylaniline

5-bromo-N-(2-fluorophenyl)-N-methylthiophene-2-carboxamide

m-tolylboronic acid

Refernces

• 1、 -. "BIARYL DERIVATIVES AS SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 INHIBITORS". Page/Page column 61-62. . Retrieved 2012/09/21.