1978-38-7Relevant articles and documents
Synthesis method of N-methyl o-fluoroaniline
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Paragraph 0018; 0024; 0026-0041, (2021/05/29)
The invention relates to the field of preparation of pesticide and medical intermediates, and in particular, relates to a preparation method of N-methyl o-fluoroaniline, wherein the preparation method comprises the following steps: by taking o-fluoroaniline as a raw material and dimethyl carbonate as a reaction raw material and a reaction solvent, carrying out heat preservation reaction under the action of a basic catalyst; and after the reaction is finished, filtering to remove the catalyst, carrying out rectification separation on filtrate, and separating the solvent dimethyl carbonate from the product. Compared with the prior art, the novel synthesis method of N-methyl o-fluoroaniline provided by the invention has the following effective effects: only one-step reaction is needed, the selectivity is extremely high, the product quality is good, the selected methylation reagent dimethyl carbonate is low in toxicity, green and safe, the output of three wastes is low, and the novel synthesis method of N-methyl o-fluoroaniline is a green chemical process with extremely competitive power.
Synthesis method of N-methyl o-fluoroaniline
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, (2020/09/23)
The invention discloses a synthesis method of N-methyl o-fluoroaniline, which comprises the following steps: an amidation reaction: by using o-fluoroaniline as a raw material, mixing o-fluoroaniline with toluene and formic acid, heating to react, and dehydrating while reacting to obtain N-(2-fluorophenyl) formamide; a methylation reaction: taking N-(2-fluorophenyl) formamide as a raw material, adding dimethyl carbonate and a catalyst, putting into an autoclave, and heating to carry out the methylation reaction so as to obtain N-methyl-N-formyl-2-fluoroaniline; and a hydrolysis reaction: takingN-methyl-N-formyl-2-fluoroaniline as a raw material, mixing the N-methyl-N-formyl-2-fluoroaniline with water and sulfuric acid, carrying out hydrolysis, and carrying out post-treatment to obtain theN-methyl o-fluoroaniline. The method has the advantages of easily available raw materials, low raw material cost, mild reaction conditions, greenness, safety, high total yield (up to 90%), and great industrial application prospect.
Manufacturing method for halogen substituted N-methylaniline
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Paragraph 0025-0029; 0031-0032; 0033; 0034; 0043, (2019/09/05)
The present invention relates to a method for manufacturing halogen-substituted N-methylaniline from halogen-substituted aniline. When halogen-substituted N-methylaniline is manufactured by using the method of the present invention, it is possible to manufacture halogen-substituted N-methylaniline without using existing methoxide sodium which has low chemical stability and is expensive, by using a low-cost base having excellent chemical stability such as potassium hydroxide or sodium hydroxide. Therefore, it is possible to reduce costs in a manufacturing process and to produce N-methylaniline with a high yield and high purity, thereby being useful for mass production as a raw material for herbicide metamifop synthesis.COPYRIGHT KIPO 2019