tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

Base Information

Chemical Name:tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate
CAS No.:337308-97-1
Molecular Formula:C₃₉H₅₆O₁₁P₂
Molecular Weight:762.815
Hs Code.:

Synonyms:tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

Suppliers and Price of tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

There total 7 articles about tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 37465-31-9
1,1-bis(diethylphosphono)ethylene

: 337308-92-6
17β-(3-benzyloxyoestra-1,3,5(10)-trienyl) methyl malonate

: 337308-97-1
tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 60 ℃; for 18h;
DOI:10.1016/S0040-4020(00)01164-9

Reference yield:

: 1660-94-2
Tetraethyl methylenediphosphonate

: 337308-97-1
tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₂NH / 0.5 h / Heating

2: 43.16 g / toluene-p-sulfonic acid / methanol / Heating

3: 57 percent / LHMDS / tetrahydrofuran / 18 h / 60 °C

With toluene-4-sulfonic acid; diethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(00)01164-9

Reference yield:

: 53-16-7
Estrone

: 337308-97-1
tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (methyloxycarbonyl) propylene bisphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / K₂CO₃ / acetone / 20 °C

2: 89 percent / NaBH₄ / methanol; CH₂Cl₂ / 3 h / 0 °C

3: 68 percent / dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

4: 57 percent / LHMDS / tetrahydrofuran / 18 h / 60 °C

With dmap; sodium tetrahydroborate; potassium carbonate; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(00)01164-9