1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine

Base Information

• Chemical Name: 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine
• CAS No.: 897661-03-9
• Molecular Formula: C₂₃H₂₇IN₂O₄
• Molecular Weight: 522.383
• Mol file: 897661-03-9.mol

Synonyms:1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine

Chemical Property of 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine

There total 4 articles about 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4-dimethoxyphenylacetyl)piperazine (139329-73-0) + 3-(4-Iodo-phenyl)-propionyl chloride (49618-02-2) → 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine (897661-03-9)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 15h;

DOI:10.1248/cpb.54.470

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine (897661-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / tetrahydrofuran / 2 h / Heating

2: 77.9 percent / aq. NaOH / CHCl₃ / 0.5 h / 20 °C

3: triethylamine / CHCl₃ / 15 h / 20 °C

With sodium hydroxide; thionyl chloride; triethylamine; In tetrahydrofuran; chloroform;

DOI:10.1248/cpb.54.470

Reference yield:

3-(4-iodophenyl)propionic acid (1643-29-4) → 1-(3,4-dimethoxyphenylacetyl)-4-[3-(4-iodophenyl)propionyl]piperazine (897661-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: triethylamine / CHCl₃ / 15 h / 20 °C

With thionyl chloride; triethylamine; In chloroform;

DOI:10.1248/cpb.54.470

upstream raw materials:

1-(3,4-dimethoxyphenylacetyl)piperazine

3-(4-Iodo-phenyl)-propionyl chloride

(3,4-Dimethoxyphenyl)acetic acid

3-(4-iodophenyl)propionic acid