N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

Base Information

Chemical Name:N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide
CAS No.:612068-42-5
Molecular Formula:C₁₈H₂₂INO₃
Molecular Weight:427.282
Hs Code.:

Synonyms:N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

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Chemical Property of N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

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Technology Process of N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

There total 11 articles about N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 612068-41-4
N-[2-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-ethyl]-2-iodo-benzamide

: 74-88-4
methyl iodide

: 612068-42-5
N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

Guidance literature:: N-[2-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-ethyl]-2-iodo-benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; for 2h;
DOI:10.1002/jccs.200300071

Reference yield: 63.0%

: 88-67-5
2-Iodobenzoic acid

: 811819-53-1
[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)ethyl]methylamine

: 612068-42-5
N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

Guidance literature:: 2-Iodobenzoic acid; With thionyl chloride; In tetrahydrofuran; at -78 ℃; for 0.5h;

[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)ethyl]methylamine; With triethylamine; In tetrahydrofuran; at -20 - 20 ℃;
DOI:10.1016/j.tet.2004.09.044

Reference yield:

: 189509-23-7
8-(2-hydroxyethyl)-1,4-dioxaspiro[4,5]decan-8-ol

: 612068-42-5
N-[2-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 54 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: 90 percent / Et₃N / tetrahydrofuran; H₂O / Heating

3.1: SOCl₂ / tetrahydrofuran / 0.5 h / -78 °C

3.2: 63 percent / Et₃N / tetrahydrofuran / -20 - 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2004.09.044