4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

Base Information

Chemical Name:4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide
CAS No.:1609530-00-8
Molecular Formula:C₂₀H₁₇FN₆O₂
Molecular Weight:392.392
Hs Code.:

Synonyms:4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

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Chemical Property of 4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

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Technology Process of 4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

There total 6 articles about 4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 4-((3-carbamoyl-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)amino)-N-methylnicotinamide

: 1609530-00-8
4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; dichloromethane; acetonitrile; at 20 - 25 ℃; Inert atmosphere;

Reference yield:

: 1609531-36-3
3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

: 1609530-00-8
4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide; 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

2: ammonium chloride; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3: Burgess Reagent / tetrahydrofuran; dichloromethane; acetonitrile / 20 - 25 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Burgess Reagent; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)-pyridin-4-yl)amino)-2-methoxy-benzoic acid

: 1609530-00-8
4-((3-cyano-2-methoxyphenyl)amino)-6-((5-fluoropyridin-2-yl)-amino)-N-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

2: Burgess Reagent / tetrahydrofuran; dichloromethane; acetonitrile / 20 - 25 °C / Inert atmosphere

With Burgess Reagent; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;