3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

Base Information

Chemical Name:3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid
CAS No.:1609531-36-3
Molecular Formula:C₁₅H₁₄ClN₃O₄
Molecular Weight:335.747
Hs Code.:

Synonyms:3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

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Chemical Property of 3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

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Technology Process of 3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

There total 2 articles about 3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1609530-95-1
4,6-dichloro-N-methylnicotinamide

: 861306-04-9
3-amino-2-methoxybenzoic acid

: 1609531-36-3
3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1021/acs.jmedchem.9b00444

Reference yield:

: 73027-79-9
4,6-dichloro-nicotinic acid

: 1609531-36-3
3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / chloroform / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 0.5 h / 20 °C

With oxalyl dichloride; sodium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; N,N-dimethyl acetamide;

Reference yield: 98.0%

: 1609531-36-3
3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

: 1609531-45-4
4-((3-carbamoyl-2-methoxyphenyl)amino)-6-chloro-N-methylnicotinamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 1h;