4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

Base Information

• Chemical Name: 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide
• CAS No.: 51-07-0
• Molecular Formula: C₁₃H₁₉N₃O
• Molecular Weight: 233.313

Synonyms:4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

Chemical Property of 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

There total 3 articles about 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-N-(2-pyrrolidin-1-yl-ethyl)-benzamide (1664-30-8) → 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide (51-07-0)

Guidance literature:

With ammonium formate; iron; In water; toluene; at 70 - 80 ℃;

DOI:10.1016/j.bmcl.2010.03.074

Reference yield:

1-(2-aminoethyl)pyrrolidine (7154-73-6) + 4-nitro-benzoyl chloride (122-04-3) → 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide (51-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine

2: hydrogen; palladium on activated charcoal

With palladium on activated charcoal; hydrogen; triethylamine;

DOI:10.1039/c5ra20012a

Reference yield:

→ 4-amino-N-(2-pyrrolidin-1-yl-ethyl)-benzamide (51-07-0)

Guidance literature:

N-(2-Pyrrolidino-aethyl)-4-nitro-benzamid, H2/Pt;

DOI:10.1021/jm00325a022

upstream raw materials:

4-nitro-N-(2-pyrrolidin-1-yl-ethyl)-benzamide

1-(2-aminoethyl)pyrrolidine

4-nitro-benzoyl chloride

Downstream raw materials:

C₂₁H₂₃F₃N₄O₂

4-{[(4-{4-morpholin-4-yl-6-[(3S)-tetrahydrofuran-3-yloxy]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}-N-(2-pyrrolidin-1-ylethyl)benzamide

Refernces

Nonenzymatic kinetic resolution of racemic 2,2,2-trifluoro-1-aryl ethanol via enantioselective acylation

10.1016/j.tet.2009.01.058

The study focuses on the nonenzymatic kinetic resolution of racemic 2,2,2-trifluoro-1-aryl ethanols, utilizing (R)-benzotetramisole as a catalyst. The aim was to achieve enantioselective acylation, which is crucial for obtaining chiral 1-substituted 2,2,2-trifluoro-ethanols, important intermediates in the synthesis of biologically active molecules. Various aryl-substituted ethanols were tested to evaluate the system's ability to differentiate between enantiomers, with a focus on the impact of different aryl groups on the enantioselectivity, as indicated by the s value. The study also optimized reaction conditions, including the choice of catalyst, acylating reagent, solvent, and reaction temperature, to maximize enantioselectivity and reaction efficiency. The chemicals used served specific purposes: (R)-benzotetramisole as the catalyst to facilitate the reaction, isobutyric anhydride as the acylating reagent to promote acylation, and diisopropyl ether as the solvent providing the appropriate polarity for the reaction. The study demonstrated that certain aryl groups, particularly phenyl and naphthyl groups, could yield high s values, indicating effective kinetic resolution. The research also provided preparative kinetic resolution examples to showcase the method's applicability in preparing enantiomerically pure 2,2,2-trifluoro-1-aryl ethanol derivatives.

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