2-phenyl-1,3,4,5-tetrahydrobenzindole

Base Information

• Chemical Name: 2-phenyl-1,3,4,5-tetrahydrobenzindole
• CAS No.: 78987-24-3
• Molecular Formula: C₁₇H₁₅N
• Molecular Weight: 233.313
• Mol file: 78987-24-3.mol

Synonyms:2-phenyl-1,3,4,5-tetrahydrobenzindole

Chemical Property of 2-phenyl-1,3,4,5-tetrahydrobenzindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-1,3,4,5-tetrahydrobenzindole

There total 13 articles about 2-phenyl-1,3,4,5-tetrahydrobenzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-phenyl-1-tosyl-1,3,4,5-tetrahydrobenzo[cd]indole → 2-phenyl-1,3,4,5-tetrahydrobenzindole (78987-24-3)

Guidance literature:

With magnesium; In methanol; at 0 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.0c00403

Reference yield: 75.0%

1-(tert-butyl)-2-phenyl-1,3,4,5-tetrahydrobenzo[cd]indole → 2-phenyl-1,3,4,5-tetrahydrobenzindole (78987-24-3)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1021/acs.joc.0c01365

Reference yield: 41.0%

N-benzoyl-1-amino-5,6,7,8-tetrahydronaphthalene (79005-34-8) → 2-phenyl-1,3,4,5-tetrahydrobenzindole (78987-24-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 18h;

DOI:10.1021/jo00335a038

upstream raw materials:

N-benzoyl-1-amino-5,6,7,8-tetrahydronaphthalene

1-amino-5,6,7,8-tetrahydronaphthalene

benzoyl chloride

(8-oxo-5,6,7,8-tetrahydro-naphthalen-1-yl)-carbamic acid tert-butyl ester

Downstream raw materials:

C₁₇H₁₄BrN

C₁₇H₁₄BrN