(S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

Base Information

Chemical Name:(S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester
CAS No.:232931-88-3
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:(S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

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Chemical Property of (S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

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Technology Process of (S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

There total 3 articles about (S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 304021-31-6
(2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 232931-88-3
(S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

Guidance literature:: With trifluoroacetic acid;
DOI:10.1021/ja9910715

Reference yield:

: 22979-35-7
Methyl phenyldiazoacetate

: 232931-88-3
(S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂(S-DOSP)4 / various solvent(s) / -50 - 58 °C

2: 72 mg / TFA / CH₂Cl₂ / 4 h / 20 °C

With Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja0290072

Reference yield:

: 232931-87-2
(R)-2-((S)-Methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 232931-88-3
(S)-[(2R,5R)-5-[(S)-methoxycarbonyl(phenyl)methyl]pyrrolidin-2-yl]phenylacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂(S-DOSP)4 / various solvent(s) / 58 °C

2: TFA

With Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; trifluoroacetic acid; In various solvent(s);
DOI:10.1021/ja9910715