(2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:304021-31-6
Molecular Formula:C₂₇H₃₃NO₆
Molecular Weight:467.562
Hs Code.:

Synonyms:(2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22979-35-7
Methyl phenyldiazoacetate

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 304021-31-6
(2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; In various solvent(s); at -50 - 58 ℃;
DOI:10.1021/ja9910715 DOI:10.1021/ja0290072

Reference yield:

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 304021-31-6
(2R,5R)-2,5-Bis-((S)-methoxycarbonyl-phenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂(S-DOSP)4 / hexane / -50 °C

2: Rh₂(S-DOSP)4 / various solvent(s) / 58 °C

With Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; In hexane;
DOI:10.1021/ja9910715