(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

Base Information

Chemical Name:(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid
CAS No.:188935-04-8
Molecular Formula:C₁₉H₃₀N₂O₅
Molecular Weight:366.458
Hs Code.:

Synonyms:(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

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Chemical Property of (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

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Technology Process of (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

There total 6 articles about (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 188935-04-8
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: Na₂CO₃ / H₂O / 4 h / Ambient temperature

2: Et₃N / Ambient temperature

3: 1.) HNO₃, Ac₂O, 2.) H₂ / 2.) Pd/C / 1.) RT, 24 h, 2.) EtOAc, 1 atm, RT, 24 h

4: 70 percent / 2,6-lutidine / CH₂Cl₂ / 10 h / 70 °C

5: aq. KOH / methanol / 72 h / 30 °C

6: NaHCO₃ / 24 h / Ambient temperature

With 2,6-dimethylpyridine; potassium hydroxide; hydrogen; nitric acid; acetic anhydride; sodium hydrogencarbonate; sodium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/jm960875h

Reference yield:

: 161646-29-3
(S)-ethyl (1-hydroxy-3-phenylpropan-2-yl)carbamate

: 188935-04-8
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / Ambient temperature

2: 1.) HNO₃, Ac₂O, 2.) H₂ / 2.) Pd/C / 1.) RT, 24 h, 2.) EtOAc, 1 atm, RT, 24 h

3: 70 percent / 2,6-lutidine / CH₂Cl₂ / 10 h / 70 °C

4: aq. KOH / methanol / 72 h / 30 °C

5: NaHCO₃ / 24 h / Ambient temperature

With 2,6-dimethylpyridine; potassium hydroxide; hydrogen; nitric acid; acetic anhydride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm960875h

Reference yield:

: 188935-00-4
Acetic acid (S)-2-ethoxycarbonylamino-3-phenyl-propyl ester

: 188935-04-8
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HNO₃, Ac₂O, 2.) H₂ / 2.) Pd/C / 1.) RT, 24 h, 2.) EtOAc, 1 atm, RT, 24 h

2: 70 percent / 2,6-lutidine / CH₂Cl₂ / 10 h / 70 °C

3: aq. KOH / methanol / 72 h / 30 °C

4: NaHCO₃ / 24 h / Ambient temperature

With 2,6-dimethylpyridine; potassium hydroxide; hydrogen; nitric acid; acetic anhydride; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm960875h