161646-29-3

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 3182-95-4 L-Phenylalaninol 
• 2244-49-7 O-ethyl S-2-pyridyl carbonothioate 
• 63-91-2 L-phenylalanine 
• 190378-48-4 N-ethoxycarbonyl-L-phenylalaninal 
• 541-41-3 chloroformic acid ethyl ester 
• 91084-05-8 methyl (S)-2-ethyloxycarbonylamino-3-phenylpropanoate 

Downstream Products

• 188935-00-4 Acetic acid (S)-2-ethoxycarbonylamino-3-phenyl-propyl ester 
• 174363-73-6 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 188935-03-7 (S)-2-[2-((S)-3-Acetoxy-2-ethoxycarbonylamino-propyl)-phenylamino]-3-methyl-butyric acid benzyl ester 
• 188935-04-8 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid 
• 188935-01-5 Acetic acid (S)-3-(2-amino-phenyl)-2-ethoxycarbonylamino-propyl ester 
• 1026740-23-7 (S)-2-[2-((S)-2-Amino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 

Relevant academic research and scientific papers

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups

Amino groups are selectively protected in good yields by reaction with O-Alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.

A 4-substituted-2-oxazolidinone cyclization method

The invention discloses a cyclization method of 4-substituted-2-oxazolidone. The method is implemented through the following steps: (1) acylation: acylating chiral alkamine in a toluene solvent by adopting chloro-formate in the presence of potassium carbonate, so as to obtain chiral alkamine acylate; (2) cyclization: carrying out cyclization reaction through taking PEG-400 as a phase transfer catalyst, thereby obtaining 4-substituted-2-oxazolidone. Compared with the prior art, the cyclization method disclosed by the invention has the advantages that the adopted phase transfer catalyst is low in cost and is free of risk, reacting steps are reduced, the cost is reduced, and the conditions are mild, so that the method is suitable for industrial production.

Copper-Catalyzed One-Pot Synthesis of N -Aryl Oxazolidinones from Amino Alcohol Carbamates

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

Functional analysis of an aspartate-based epoxidation catalyst with amide-to-alkene peptidomimetic catalyst analogues

Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure-dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action. (Chemical Equation Presented).

Modified Mg: Al hydrotalcite in the synthesis of oxazolidin-2-ones

The modified Mg: Al (3: 1) hydrotalcite has been found to be an efficient catalyst in the conversion of carbamates into oxazolidin-2-ones under mild reaction conditions. A wide variety of oxazolidin-2-ones were obtained with excellent chemical yield. The Royal Society of Chemistry 2005.

P[(S,S,S)-CH3NCH(CH2Ph)CH2]3N: A new C3-symmetric enantiomerically pure proazaphosphatrane

A new approach for the synthesis of C3-symmetric proazaphosphatranes with chirality at the bridging methylene positions is reported. Graphical abstract

A high-yielding low-cost facile synthesis of 2-oxazolidinones chiral auxiliaries

The chiral aminol alcohols from reduction of amino acids with NaBH4/H2SO4 were directly treated with EtO2CCl to give the carbamates, which cyclized in the presence of traces of K2CO3 at 100-130°C under vacuum to afford chiral 2-oxazolidinones in high yields. (C) 2000 Elsevier Science Ltd.

Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCδ and discovery of an ILV analogue of improved isozyme selectivity

Protein kinase C (PKC) is a complex enzyme system comprised of at least 11 isozymes that serves to mediate numerous extracellular signals which generate lipid second messengers. The discovery of isozyme-selective activators and inhibitors (modulators) of

A simple and efficient procedure for the preparation of chiral 2-oxazolidinones from α-amino acids

A modified procedure for the title transformation is described which avoids: (i) a potentially hazardous borane reduction step, and (ii) the intermediacy of water soluble amino alcohols.