({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

Base Information

Chemical Name:({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester
CAS No.:430459-94-2
Molecular Formula:C₄₈H₅₇F₂NO₁₅
Molecular Weight:925.975
Hs Code.:

({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

Synonyms:({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

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Chemical Property of ({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

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Technology Process of ({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

There total 16 articles about ({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 430459-89-5
(tert-butoxycarbonylmethyl-{4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-2-hydroxy-phenyl}-amino)-acetic acid tert-butyl ester

: 5437-45-6
Benzyl bromoacetate

: 430459-94-2
({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

Guidance literature:: (tert-butoxycarbonylmethyl-{4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-2-hydroxy-phenyl}-amino)-acetic acid tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Benzyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; Further stages.;
DOI:10.1021/ja017530v

Reference yield:

: 430459-61-3
5-fluoro-2,4-dimethoxy-benzonitrile

: 430459-94-2
({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 93 percent / NaOH / methanol; H₂O / Heating

2.1: oxalyl chloride / CH₂Cl₂ / 20 °C

3.1: AlCl₃ / CH₂Cl₂ / 68 h / 0 - 20 °C

4.1: 3.3 g / aq. HCl / 0 °C

5.1: 83 percent / H₂O / 3 h / 200 - 220 °C

6.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

6.2: 65 percent / tetrahydrofuran / 20 °C

7.1: tBuLi / tetrahydrofuran; pentane; various solvent(s) / 0.25 h / -105 °C

7.2: 69 percent / tetrahydrofuran; pentane; various solvent(s) / 0.5 h / -105 °C

8.1: 78 percent / H₂ / Pd/C / aq. ethanol; ethyl acetate / 20 °C / 760.05 Torr

9.1: NaH / dimethylformamide / 0.5 h / 0 °C

9.2: 76 percent / dimethylformamide / 20 °C

With hydrogenchloride; sodium hydroxide; aluminium trichloride; oxalyl dichloride; water; hydrogen; tert.-butyl lithium; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; pentane; 3.1: Friedel-Crafts acylation;
DOI:10.1021/ja017530v

Reference yield:

: 430459-68-0
[tert-butoxycarbonylmethyl-(2-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester

: 430459-94-2
({2-benzyloxycarbonylmethoxy-4-[2,7-difluoro-9-hydroxy-3,6-bis(2-methoxyethoxymethoxy)-9H-xanthen-9-yl]-phenyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 67 percent / tetrahydrofuran / 20 °C

2.1: 79 percent / pyridine; bromine / CH₂Cl₂ / 0.5 h / -78 °C

3.1: tBuLi / tetrahydrofuran; pentane; various solvent(s) / 0.25 h / -105 °C

3.2: 69 percent / tetrahydrofuran; pentane; various solvent(s) / 0.5 h / -105 °C

4.1: 78 percent / H₂ / Pd/C / aq. ethanol; ethyl acetate / 20 °C / 760.05 Torr

5.1: NaH / dimethylformamide / 0.5 h / 0 °C

5.2: 76 percent / dimethylformamide / 20 °C

With pyridine; hydrogen; bromine; tert.-butyl lithium; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ja017530v