(E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

Base Information

Chemical Name:(E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide
CAS No.:661462-01-7
Molecular Formula:C₃₁H₄₇NO₄Si
Molecular Weight:525.804
Hs Code.:

Synonyms:(E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

Suppliers and Price of (E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

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Technology Process of (E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

There total 8 articles about (E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 661462-00-6
(E)-N-[(S)-4-tert-butyldimethylsilyloxy-3-tert-butyldiphenylsilyloxybutyl]-3-tert-butyldimethylsilyloxy-2-methyldec-8-enamide

: 661462-01-7
(E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 40 ℃; for 24h;
DOI:10.3987/com-03-s64

Reference yield:

: 661461-98-9
(S)-4-azido-1-tert-butyldimethylsilyloxy-2-tert-butyldiphenylsilyloxybutane

: 661462-01-7
(E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10 percent Pd-C / ethyl acetate / 3 h / 20 °C

2: 3.21 g / triethylamine / CH₂Cl₂ / 3 h / 20 °C

3: 86 percent / p-TsOH / CH₂Cl₂ / 24 h / 40 °C

With hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.3987/com-03-s64

Reference yield:

: 63196-63-4
(E)-oct-6-enal

: 661462-01-7
(E)-N-[(S)-4-hydroxy-3-tert-butyldiphenylsilyloxybutyl]-3-hydroxy-2-methyldec-8-enamide

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / activated zinc / benzene / 2 h / Heating

2: 85 percent / imidazole / dimethylformamide / 10 h / 20 °C

3: 92 percent / aq. LiOH / tetrahydrofuran; methanol / 72 h / 20 °C

4: oxalyl chloride / benzene / 2 h / 20 °C

5: 3.21 g / triethylamine / CH₂Cl₂ / 3 h / 20 °C

6: 86 percent / p-TsOH / CH₂Cl₂ / 24 h / 40 °C

With 1H-imidazole; lithium hydroxide; oxalyl dichloride; toluene-4-sulfonic acid; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Reformatsky reaction;
DOI:10.3987/com-03-s64