diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate

Base Information

• Chemical Name: diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate
• CAS No.: 174575-03-2
• Molecular Formula: C₁₂H₁₇Br₂O₃P
• Molecular Weight: 400.047
• Mol file: 174575-03-2.mol

Synonyms:diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate

Chemical Property of diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate

There total 2 articles about diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-bromo-3,5-bis(bromomethyl)benzene (51760-23-7) + triethyl phosphite (122-52-1) → diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate (174575-03-2)

Guidance literature:

In xylene; for 2h; Heating;

DOI:10.1002/hlca.19950780810

Reference yield:

5-bromo-1,3-dihydroxymethylbenzene (51760-22-6) → diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate (174575-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PPh₃ / toluene / 2 h / 80 °C

2: 47 percent / xylene / 2 h / Heating

With triphenylphosphine; In toluene; xylene;

DOI:10.1002/hlca.19950780810

Reference yield: 95.0%

tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (119838-44-7) + diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate (174575-03-2) → 1,1-dimethylethyl (2R,5R)-5-<<3-bromo-5-<(diethoxyphosphoryl)methyl>phenyl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (174690-38-1)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 ℃; for 1.66667h;

DOI:10.1002/hlca.19950780810

upstream raw materials:

1-bromo-3,5-bis(bromomethyl)benzene

triethyl phosphite

5-bromo-1,3-dihydroxymethylbenzene

Downstream raw materials:

1,1-dimethylethyl (2R,5R)-5-<<3-bromo-5-<(diethoxyphosphoryl)methyl>phenyl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

1,1-dimethylethyl (2S,5S)-5-<<3-bromo-5-<(diethoxyphosphoryl)methyl>phenyl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

(S)-α-amino-5-(phosphonomethyl)<1,1'-biphenyl>-3-propanoic acid

1,1-dimethylethyl (2S,5S)-5-<<5-<(diethoxyphosphoryl)methyl><1,1'-biphenyl>-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate