(2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

Base Information

Chemical Name:(2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane
CAS No.:127331-97-9
Molecular Formula:C₁₇H₁₇F₃O₂S
Molecular Weight:342.382
Hs Code.:

Synonyms:(2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

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Technology Process of (2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

There total 2 articles about (2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 100-39-0
benzyl bromide

: 113965-65-4
(2R)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propan-2-ol

: 127331-97-9
(2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 0.05h;
DOI:10.1021/jo00300a051

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 127331-97-9
(2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

Guidance literature:: Multi-step reaction with 2 steps

2: 93 percent / sodium hydride / dimethylformamide / 0.05 h

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo00300a051

Reference yield:

: 127331-97-9
(2R)-3-(benzyloxy)-1,1,1-trifluoro-3(R)-<(4-methylphenyl)sulfinyl>propane

: 127331-99-1
(S)-O-benzyl-3,3,3-trifluorolactic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 2,4,6-trimethylpyridine, 2) mercury(II) chloride / 1) acetonitrile, 1h, room temp., 2) water, 2h

2: 80 percent / sodium chlorite, aq. potassium dihydrogen phosphate / 2-methyl-propan-2-ol; various solvent(s) / 1.5 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; sodium chlorite; potassium dihydrogenphosphate; mercury dichloride; In tert-butyl alcohol;
DOI:10.1021/jo00300a051