Technology Process of (R)-3-(2-chlorophenyl)cyclohexan-1-one
There total 2 articles about (R)-3-(2-chlorophenyl)cyclohexan-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-Chlorobenzeneboronic acid;
With
chlorobis(ethylene)rhodium(I) dimer; (+)-(1R,4R,5R,8R)-4,8-bis(3,5-dimethylphenyl)-4,8-dimethoxybicyclo[3.3.1]nona-2,6-diene;
In
tetrahydrofuran;
at 50 ℃;
for 0.25h;
Inert atmosphere;
cyclohexenone;
With
potassium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 3h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/cctc.202100638
- Guidance literature:
-
2-Chlorobenzeneboronic acid;
With
chloro(ethylene)rhodium(I) dimer; (3R,4R)-1,5-hexadiene-3,4-diol;
In
1,4-dioxane;
at 50 ℃;
Inert atmosphere;
cyclohexenone;
With
potassium hydroxide;
In
1,4-dioxane; water;
at 20 ℃;
for 3h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/ol901949n
