2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Base Information

Chemical Name:2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
CAS No.:1356009-98-7
Molecular Formula:C₂₆H₂₂Cl₂F₂N₆O₃
Molecular Weight:575.402
Hs Code.:

Synonyms:2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Chemical Property of 2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Technology Process of 2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

There total 7 articles about 2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 1263869-63-1
2,4-dichloro-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 1356009-18-1
3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)-N-methylpropan-1-amine

: 1356009-98-7
2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 1009-36-5
2-chloro-5-nitroanisole

: 1356009-98-7
2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / -78 - 4 °C / Inert atmosphere

2.1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

4.2: 2 h / 70 °C

5.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 3 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With hydrogenchloride; boron tribromide; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 619-10-3
5-nitro-2-chlorophenol

: 1356009-98-7
2-chloro-N-(3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl)-7-(2,4-difluorophenyl)-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 2 h / 70 °C

4.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 3 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With hydrogenchloride; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;