Cyclobutanecarboxamide, 3,3-difluoro- (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxamide, 3,3-difluoro- (9CI)
• CAS No.: 86770-82-3
• Molecular Formula: C5H7 F2 N O
• Molecular Weight: 135.113
• Mol file: 86770-82-3.mol

Synonyms:Cyclobutanecarboxamide, 3,3-difluoro- (9CI)

Chemical Property of Cyclobutanecarboxamide, 3,3-difluoro- (9CI)

Chemical Property:

• PSA: 43.09000
• LogP: 1.21730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3,3-Difluorocyclobutanecarboxamide 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,3-Difluorocyclobutanecarboxamide is used in preparation of Dihydroisoquinoline compound and application for preventing or treating hepatitis B.

Technology Process of Cyclobutanecarboxamide, 3,3-difluoro- (9CI)

There total 3 articles about Cyclobutanecarboxamide, 3,3-difluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxo-cyclobutanecarbonitrile (20249-16-5) → 3,3-difluorocyclobutane-1-carboxamide (86770-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylaminosulfur trifluoride / CH₂Cl₂ / 18 h / 20 °C

2: 3.5 g / sodium hydroxide / methanol; H₂O / 75 h / 20 - 60 °C

With sodium hydroxide; diethylamino-sulfur trifluoride; In methanol; dichloromethane; water;

DOI:10.1081/SCC-200050350

Reference yield:

3-methylenecyclobutanecarbonitrile (15760-35-7) → 3,3-difluorocyclobutane-1-carboxamide (86770-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / sodium metaperiodate; ruthenium(III) trichloride monohydrate / CH₂Cl₂; acetonitrile; H₂O / 18 h / 20 °C

2: diethylaminosulfur trifluoride / CH₂Cl₂ / 18 h / 20 °C

3: 3.5 g / sodium hydroxide / methanol; H₂O / 75 h / 20 - 60 °C

With ruthenium trichloride; sodium hydroxide; sodium periodate; diethylamino-sulfur trifluoride; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1081/SCC-200050350

Reference yield:

3,3-difluorocyclobutane-1-carbonitrile (86770-80-1) → 3,3-difluorocyclobutanecarboxylic acid (107496-54-8) + 3,3-difluorocyclobutane-1-carboxamide (86770-82-3)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 - 60 ℃; for 75h;

DOI:10.1081/SCC-200050350

upstream raw materials:

3,3-difluorocyclobutane-1-carbonitrile

3-methylenecyclobutanecarbonitrile

3-oxo-cyclobutanecarbonitrile

Downstream raw materials:

3,3-difluorocyclobutylamine hydrochloride