2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

Base Information

Chemical Name:2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide
CAS No.:218629-71-1
Molecular Formula:C₂₄H₂₂N₄O₄S
Molecular Weight:462.529
Hs Code.:

2-(3-methoxy-phenyl)-5-methyl-2<i>H</i>-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

Synonyms:2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

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Chemical Property of 2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

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Technology Process of 2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

There total 6 articles about 2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39232-91-2
m-methoxyphenylhydrazine hydrochloride

: 218629-71-1
2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH / 2-methoxy-ethanol / 105 °C

2.1: trimethylaluminum / CH₂Cl₂; hexane / 0.25 h / 0 °C

2.2: CH₂Cl₂; hexane / 0 - 20 °C

3.1: 440 mg / trifluoroacetic acid / 1 h / Heating

With trimethylaluminum; acetic acid; trifluoroacetic acid; In hexane; dichloromethane; 2-methoxy-ethanol;
DOI:10.1021/jm030212h

Reference yield:

: 615-79-2
ethyl 2,4-diketopentanoate

: 218629-71-1
2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 40 percent / 3A molecular sieves / ethanol / 18 h

2.1: AcOH / 2-methoxy-ethanol / 105 °C

3.1: trimethylaluminum / CH₂Cl₂; hexane / 0.25 h / 0 °C

3.2: CH₂Cl₂; hexane / 0 - 20 °C

4.1: 440 mg / trifluoroacetic acid / 1 h / Heating

With 3 A molecular sieve; trimethylaluminum; acetic acid; trifluoroacetic acid; In ethanol; hexane; dichloromethane; 2-methoxy-ethanol;
DOI:10.1021/jm030212h

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 218629-71-1
2-(3-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / CH₂Cl₂; hexane / 0.25 h / 0 °C

1.2: CH₂Cl₂; hexane / 0 - 20 °C

2.1: 440 mg / trifluoroacetic acid / 1 h / Heating

With trimethylaluminum; trifluoroacetic acid; In hexane; dichloromethane;
DOI:10.1021/jm030212h