2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Base Information

Chemical Name:2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid
CAS No.:1477523-98-0
Molecular Formula:C₂₇H₃₁N₃O₄
Molecular Weight:461.561
Hs Code.:

Synonyms:2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

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Chemical Property of 2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

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Technology Process of 2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

There total 10 articles about 2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1477524-56-3
{1-[4'-(5-tert-butyl-[1,3,4]oxadiazol-2-ylamino)biphenyl-4-yl]-2-oxa-bicyclo[2.2.2]oct-4-yl}acetic acid methyl ester

: 1477523-98-0
2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; water; at 50 ℃; for 2h;

Reference yield:

: 1449661-70-4
4-trifluoromethanesulfonyloxycyclohex-3-ene-1,1-dicarboxylic acid diethyl ester

: 1477523-98-0
2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 3,3-Dimethylbut-1-yne; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,2-dimethoxyethane; ethanol / 16 h / 80 °C / Inert atmosphere; Sealed tube

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1.5 h / -78 - 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

5.2: 0.17 h / 20 °C

6.1: pyridinium chlorochromate / dichloromethane; tetrahydrofuran / 62 h / 20 °C

7.1: nickel dichloride; sodium tetrahydroborate; methanol / water; tetrahydrofuran; ethyl acetate; chlorobenzene / 0.67 h / -30 - 20 °C

8.1: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

9.1: lithium hydroxide monohydrate / water; tetrahydrofuran; ethanol / 2 h / 50 °C

With methanol; sodium tetrahydroborate; potassium phosphate; N-Bromosuccinimide; lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; 3,3-Dimethylbut-1-yne; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium tert-butylate; Dess-Martin periodane; cesium fluoride; pyridinium chlorochromate; nickel dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate; chlorobenzene; 1.1: |Suzuki Coupling / 5.1: |Wittig Olefination / 5.2: |Wittig Olefination;

Reference yield:

: 55704-60-4
4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester

: 1477523-98-0
2-(1-(4'-((5-tert-butyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.53 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: 3,3-Dimethylbut-1-yne; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,2-dimethoxyethane; ethanol / 16 h / 80 °C / Inert atmosphere; Sealed tube

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 - 20 °C

4.1: N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane / 1.5 h / -78 - 20 °C

6.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

6.2: 0.17 h / 20 °C

7.1: pyridinium chlorochromate / dichloromethane; tetrahydrofuran / 62 h / 20 °C

8.1: nickel dichloride; sodium tetrahydroborate; methanol / water; tetrahydrofuran; ethyl acetate; chlorobenzene / 0.67 h / -30 - 20 °C

9.1: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

10.1: lithium hydroxide monohydrate / water; tetrahydrofuran; ethanol / 2 h / 50 °C

With methanol; sodium tetrahydroborate; potassium phosphate; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; 3,3-Dimethylbut-1-yne; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium tert-butylate; Dess-Martin periodane; diisopropylamine; cesium fluoride; pyridinium chlorochromate; nickel dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; ethyl acetate; chlorobenzene; 2.1: |Suzuki Coupling / 6.1: |Wittig Olefination / 6.2: |Wittig Olefination;