55704-60-4

Usage

Uses

Used in Organic Synthesis:
DIETHYL 4-OXOCYCLOHEXANE-1,1-DICARBOXYLATE is used as an intermediate for [application reason] in the production of other chemicals. Its role is crucial in organic synthesis, allowing for the creation of a wide range of compounds with various applications across different industries.

InChI:InChI=1S/C12H18O5/c1-3-16-10(14)12(11(15)17-4-2)7-5-9(13)6-8-12/h3-8H2,1-2H3

Upstream product

• 92454-00-7 pentane-1,3,3,5-tetracarboxylic acid-3,3-diethyl ester 
• 57899-62-4 triethyl 4-oxocyclohexane-1,1,3-tricarboxylate 
• 3377-20-6 diethyl methylenemalonate 
• 105-53-3 diethyl malonate 
• 103157-86-4 pentane-1,3,3,5-tetracarboxylic acid-3,3-diethyl ester-1,5-dibenzyl ester 
• 6297-36-5 1,3,3,5-pentanetetracarboxylic acid tetraethyl ester 

Downstream Products

• 5408-02-6 3,3,5,5-tetrakis-(2-cyano-ethyl)-4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 6493-77-2 methyl cyclohex-3-ene-1-carboxylate 
• 58774-03-1 4-oxo-cyclohexane-1,1-dicarboxylic acid dimethyl ester 
• 41079-58-7 dimethyl cyclohex-3-ene-1,1-dicarboxylate 
• 92454-01-8 dimethyl 4-hydroxycyclohexane-1,1-dicarboxylate 
• 92454-02-9 4-(Toluene-4-sulfonyloxy)-cyclohexane-1,1-dicarboxylic acid dimethyl ester 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 5408-01-5 3,3,5,5-tetrakis-(2-carboxy-ethyl)-4-oxo-cyclohexanecarboxylic acid 
• 1374683-91-6 2-benzoyloxy-4,4-dicarbethoxycyclohexanone 
• 340022-81-3 (4-oxocyclohexane-1,1-diyl)bis(methylene) bis(4-methylbenzenesulfonate) 
• 1256546-72-1 [8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol 
• 1380665-32-6 N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester 
• 1380665-41-7 N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-7-(hydroxymethyl)-4-oxo-3-(phenylmethoxy)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide 

Relevant academic research and scientific papers

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists

An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that the cyclohexane carboxylic acid group of compound 2 plays a significant role in RORγt binding, forming four hydrog

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents

Bacterial resistance is eroding the clinical utility of existing antibiotics necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly effective, and proven drug target. This target is amenable to inhibit

BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Novel bridged bicyclic compounds are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antibacterial agents. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating bacterial infections and associated diseases and conditions.

HIV INTEGRASE INHIBITORS

The disclosure generally relates to the novel compounds of formula (I), including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invent

Synthesis of cobalt-substituted 1,3-diene complexes with unusual structures and their exo-selective Diels-Alder reactions

The synthesis and characterization (including crystallographic data) of several substituted-pyridine (Rpyr) cobalt bis(dimethylglyoxime) 1,3-butadiene complexes (R = H, tBu, 3,5-diMe, and N,N-dimethylamino) and their Diels-Alder reactions with a variety of dienophiles are reported here. The cobalt-carbon bonds in the Diels-Alder cycloadducts can be cleaved so that cobalt complexes as well as functionalized organic cycloadducts are recovered. Through these cobalt-carbon bond cleavage reactions, cobalt-diene complexes can serve as synthons for a variety of 1,3-dienes such as 1,3-butadiene, 2-(trimethylsiloxy)- 1,3-butadiene, iodoprene, (E)-1-methoxy-3-(trimethylsiloxy)-1,3-butadiene (Danishefsky's diene), and 1,2-dichloro-1,3-butadiene. The preparation of several cobalt-substituted 1,2- and 1,3-pentadiene complexes and highly exo-selective Diels-Alder reactions of the 1,3-pentadiene complexes are then discussed followed by demetalation reactions of these more highly substituted cobalt cycloadducts. These demetalation reactions maintain the stereochemical integrity found in the metal cycloadducts and also lead to cobalt recovery.

FACILE SYNTHESIS OF 4-CARBETHOXYCYCLOHEXANONE

A facile decarboalkoxylative route to 4-carbethoxycyclohexanone (1) from the tricarbethoxy derivative 3 is described.

LACTONE FORMATION USING TMSI

Iodotrimethylsilane facilitates the rapid lactonization of alcohol ester 2 under remarkably mild conditions.